"These are (1) the production in the blood of an antidote to the toxin or poison elaborated by the invading microbe -- an antitoxin, which chemically neutralises the toxin; (2) the production in the blood of the attacked animal of a "germicidal" poison which repels and kills the attacking microbes themselves (not merely neutralising their poisonous products); (3) the extermination of the intrusive, disease-producing microbes by a kind of police, which scour the blood channels and tissues and "eat up" -- actually engulf and digest -- the hostile intruders."