noun. The act of exacerbating, or the state of being exacerbated; increase of violence or virulence; aggravation; exasperation.

noun. In medicine, an increase of violence in a disease; specifically, the periodical aggravation of the febrile condition in remittent and continued fevers: as, nocturnal exacerbations.

noun. The act of rendering more violent or bitter; the state of being exacerbated or intensified in violence or malignity.

noun. A periodical increase of violence in a disease, as in remittent or continuous fever; an increased energy of diseased and painful action.

noun. An increase in the severity of something (such as a disease)

noun. action that makes a problem or a disease (or its symptoms) worse

noun. violent and bitter exasperation

"A significant worsening of symptoms - called an exacerbation - can last several weeks and often requires substantial medical intervention, including hospitalization."

exacerbate  

exasperation  intensification  

Alsatian  Americanization  Appalachian  Balkanization  Christianization  

appendicitis  berserker  blowup  catatonia  decompensation  

accelerando  acceleration  aggravation  agitation  amplification