noun. Loss or lack of stability or equilibrium.

noun. An imperfect equilibrium, as of intellectual and moral faculties.

noun. the loss of equilibrium or stability, especially due to an imbalance of forces

noun. loss of equilibrium attributable to an unstable situation in which some forces outweigh others

"Classically trained professionals and laypeople alike offered similar explanations for why people fell sick: the body's four humors had been thrown out of balance, causing one or more of these fluids to be in disequilibrium with the others."