"The choice of solvent is important, for the velocity of the reaction and the nature of the product may vary according to the solvent used, thus A. Baeyer and F. Blom found that on brominating orthoacetamido-acetophenone in presence of water or acetic acid, the bromine goes into the benzene nucleus, whilst in chloroform or sulphuric acid or by use of bromine vapour it goes into the side chain as well."